你这连个来源都没有,不过理工科查个文献好像不太难
https://ccforum.biomedcentral.com/articles/10.1186/s13054-016-1230-8 Results
Among 607 patients, corticosteroids were administered to 280 patients (46.1 %) at a median daily dose of 227 (interquartile range, 154–443) mg of hydrocortisone equivalents for a median of 7.0 (4.0–13.0) days. Compared with patients who did not receive corticosteroids, patients who received corticosteroids had higher hospital crude mortality (25.5 % vs 16.4 %, p = 0.007) and fewer ventilator-free days at 28 days (12.5 ± 10.7 vs 15.7 ± 10.1, p < 0.001). The odds ratio association between corticosteroid use and hospital mortality decreased from 1.85 (95 % confidence interval 1.12–3.04, p = 0.02) with multivariate logistic regression, to 1.71 (1.05–2.78, p = 0.03) after adjustment for propensity score to receive corticosteroids, to 1.52 (0.90–2.58, p = 0.12) after case-matching on propensity score, and to 0.96 (0.28–3.28, p = 0.95) using marginal structural modeling to adjust for time-dependent between-group differences.
Conclusions
Corticosteroids were commonly prescribed for H1N1pdm09-related critical illness. Adjusting for only baseline between-group differences suggested a significant increased risk of death associated with corticosteroids. However, after adjusting for time-dependent differences, we found no significant association between corticosteroids and mortality. These findings highlight the challenges and importance in adjusting for baseline and time-dependent confounders when estimating clinical effects of treatments using observational studies.
重点:1、corticosteroids were administered to 280 patients (46.1 %) at a median daily dose
of 227 (interquartile range, 154–443) mg of hydrocortisone equivalents for a
median of 7.0 (4.0–13.0) days.
2、we found no significant association between corticosteroids and mortality.
翻译成中文就是,实验中激素用量大概相当于我的方案的20倍到30倍,最终的结论是死亡率和激素使用没有显著相关性
【 在 senyu2 的大作中提到: 】
: 流感领域的研究,5倍死亡率
: Early corticosteroid treatment was independently associated with increased hospital mortality in overall patients [adjusted odds ratio (95% CI) = 5.02 (2.39–10.54), p < 0.001] and in all subgroups.
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FROM 117.65.211.*