LC-MS/MS灵敏度应该是够了,再检测不出来就真没办法了。
如果绝大部分ITPP都结合在血红蛋白上,那么基于血清或者血浆的检测也不行,需要用全血,技术上不存在瓶颈。
【 在 wahrheit 的大作中提到: 】
: 美国职业橄榄球运动员是否接受药检?Wikipedia上说可以用液相色谱-质谱联用法(liquid chromatography–mass spectrometry,LC-MS)来检测ITPP。
: myo-Inositol trispyrophosphate (ITPP) is an inositol phosphate, a pyrophosphate, a drug candidate, and a putative performance-enhancing substance, which exerts its biological effects by increasing tissue oxygenation.
: ITPP is a pyrophosphate derivative of phytic acid with the molecular formula C6H12O21P6. The substance is believed to have a high potential for use in athletic doping, and liquid chromatography–mass spectrometry tests have been developed to detect ITPP in urine tests. Its use as a performance-enhancing substance in horse racing has also been suspected and similar tests have been developed for horses.
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