屏保的没试过，锁屏的我倒处理过：

class WinSessionManager:
    def __init__(self):
        self.last_unlock = 0
        self.is_active = None
        self.is_locked = None

    def update_lock_status(self):
        hwnd = win32gui.GetForegroundWindow()
        if hwnd == 0:
            self.is_locked = True
        else:
            self.is_locked = False

    def get_current_rdp_session(self):
        '''
        get current rdp session id, *also force an update of lock status*
        :return: current rdp session id
        '''
        self.update_lock_status()
        complete = subprocess.run('chcp 437 | query session', capture_output=True, shell=True, encoding='gbk')
        cmd_text: str = complete.stdout
        logging.debug('get_current_rdp_session():')
        logging.debug(cmd_text)
        for line in cmd_text.splitlines():
            line = line.strip()
            if line.startswith('>'):
                line_splits = line.split()
                rdp_session_id = int(line_splits[2])
                if line_splits[3].lower() == 'disc':
                    self.is_active = False
                elif line_splits[3].lower() == 'active':
                    self.is_active = True
                return rdp_session_id

    def lock_screen(self):
        rdp_session = self.get_current_rdp_session()
        if self.is_active:
            logging.debug('Calling tsdiscon..')
            return_code = subprocess.call(['tsdiscon.exe', str(rdp_session)], shell=True)
            logging.debug(f'tsdiscon: return code: {return_code}')
            while True:
                self.get_current_rdp_session()
                if not self.is_active:
                    break

    def unlock_screen(self):
        rdp_session = self.get_current_rdp_session()
        self.last_unlock = time.time()
        if self.is_active and self.is_locked:
            # locked from console, disconnect the session first
            logging.debug('Locked from console detected, disconnect first.')
            self.lock_screen()

        if not self.is_active:
            logging.debug('Calling tscon..')
            return_code = subprocess.call(['tscon.exe', str(rdp_session), '/dest:console'],
                                          shell=True)
            logging.debug(f'tscon: return code: {return_code}')
            while True:
                self.get_current_rdp_session()
                if self.is_active:
                    break


【 在 Algoquant 的大作中提到: 】
: 发现很多python库 或者 nircmd.EXE （nircmd.exe sendkeypress ctrl）都是 模拟键盘或者鼠标操作，能够在当前会话 控制不用进入屏保或者 当前会话发起的屏保能够自动解除，
: 但是当系统发起的屏保时，这些程序就没法工作了，AI 说是windows系统发起的具有UI隔离，输入通道受限 ，所以没办法 用程序定时 取消屏保。
: 有没人知道相关的解决方案，除了 直接关闭系统 屏保功能。
: ...................
--
修改:adamhj FROM 182.96.96.*
FROM 182.96.96.*