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Association of Childhood Growth Hormone Treatment With Long-term Cardiovascular Morbidity

Key Points
Question  Is childhood growth hormone treatment associated with an increased long-term risk of cardiovascular morbidity?

Findings  In this nationwide population-based cohort study of 3408 patients treated with growth hormone in childhood and followed up for 25 years, risk of cardiovascular events later in life was increased compared with 50 036 age-, sex-, and region-matched control individuals adjusted for possible confounders. Longer duration of treatment and higher cumulative dose further increased this risk.

Meaning  These findings suggest that childhood growth hormone treatment is associated with an increased risk of cardiovascular events in early adulthood, although conclusions of causality are limited and the absolute risks are low.

https://jamanetwork.com/journals/jamapediatrics/article-abstract/2773797
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