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Project Description: 2011 Bioinformatics Intern/distance
internship. At this time, we have two openings for research
intern/distance intern at the Biomedical Cybernetics Laboratory with
faculty affiliated with Harvard and MIT. Our projects involve
machine learning and network analysis method
development, and application to bring bottom-up data-driven (e.g.
Bayesian network learning) and top-down knowledge-driven approaches
(ontologies) together and abstract out key information/underlying
relationships. These projects involve work with a laboratory
affiliated with the Children's Hospital Informatics Program at the
Harvard/MIT Division of Health Sciences and Technology and the
Center for Biomedical Informatics at Harvard Medical School.
There are two opportunities that require strong programming skills
(medicine/molecular biology, CS, engineering, math, and/or physics
background a plus). For one opportunity, a strong background in
medicine/molecular biology, genetics, and evolution would be a plus.
For the other opportunity, a background in probability, network
theory, linear algebra, machine learning, and/or signal processing
would be a plus.
One research project involves work on biomolecular and knowledge
networks. Specifically, we are looking at learning new knowledge
(applicable to diseases) from large, interconnected biological
datasets. This project involves developing inference framework from
biomedical molecular experiments through cutting-edge learning and inference
techniques over Bayesian networks.
The other opportunity involves working with genome-scale data to
capture the complex pattern of dependency among causal genetic and
environmental variants for several diseases and behaviors such as lung
cancer, pancreatic cancer, alcoholism, and nicotine dependence. The
goal of this project is to integrate the small to moderate effect size
of many causal variants underlying complex traits to obtain a
comprehensive picture of the traits. We will construct prognostic
models able to predict the risk of developing of the traits.
Some features of this particular opportunity include:
- Potential for a high-impact publication by the end of the opportunity
(previous students alums have won national awards and have been
accepted to top graduate/medical programs including Harvard MD/PhD).
- Networking at Harvard/MIT community via lab meetings,
journal club, seminars, etc.
- A self-contained project that can be done within a semester or two-
but also has room for expansion for the ambitious student.
- Flexible work hours
- Independence (can be a plus or minus- i.e. student must be highly
motivated and put in the time to be successful).
- Flexible start/end dates. Please note that this opportunity may be
either for-credit, experience, or potentially funding.
- Can work from abroad and/or come to US for summers,term,etc. In the
past, this led to a masters thesis for the international student.
- Please apply asap as the 2 positions are being filled on rolling basis.
Contact: Please send a CV to Aaron Merlob at (alterovitzra@mit.edu) if you
are interested.
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