【 以下文字转载自 People 讨论区 】
发信人: wahrheit (   ), 信区: People
标  题: 专业人士解释美国游泳队“紫薯脸”，可能服用禁药ITPP。
发信站: 水木社区 (Wed Aug 14 18:01:23 2024), 站内

Wikipedia上说可以用液相色谱-质谱联用法（liquid chromatography–mass spectrometry，LC-MS）来检测ITPP。

myo-Inositol trispyrophosphate (ITPP) is an inositol phosphate, a pyrophosphate, a drug candidate, and a putative performance-enhancing substance, which exerts its biological effects by increasing tissue oxygenation.

ITPP is a pyrophosphate derivative of phytic acid with the molecular formula C6H12O21P6. The substance is believed to have a high potential for use in athletic doping, and liquid chromatography–mass spectrometry tests have been developed to detect ITPP in urine tests. Its use as a performance-enhancing substance in horse racing has also been suspected and similar tests have been developed for horses.

ITPP is a membrane-permeant allosteric regulator of hemoglobin that mildly reduces its oxygen-binding affinity, which shifts the oxygen-hemoglobin dissociation curve to the right and thereby increases oxygen release from the blood into tissue. Phytic acid, in contrast, is not membrane-permeant due to its charge distribution.

Rodent studies in vivo demonstrated increased tissue oxygenation and dose-dependent increases in endurance during physical exercise, in both healthy mice and transgenic mice expressing a heart failure phenotype.

发信人: youyo (you and me), 信区: NewExpress
标 题: Re: 外网有专业人士解释紫薯脸用药细节了
发信站: 水木社区 (Tue Aug 13 19:59:58 2024), 站内

肌醇三焦磷酸在人体内本身含量很高，不知道这个肌醇三焦磷酸是不是很快代谢成内源性物质。
按理说也能够检测，只不过以前可能没有针对性开发检测方法。
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修改:wahrheit FROM 175.9.224.*
FROM 175.9.224.*